Environment variable changes using SSIS

If I change an system Environment variable on a server what do I need to do to see the change from these locations:

SSMS connected remotely
SQL Agent Job
SSMS connected to SSIS remotely starting jobs

Does SQL Server, SQL Agent, SSIS service need to be restarted?

I was running some tests against a package and the package ran fine when I was on the server, but had errors from remote locations.  I'm being told it was due to a change in the environment variable.